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My interest in PACS and imaging informatics was inspired and deeply in uenced by Dr Robert S Ledley and initially by his book Use of Computers in Biology and Medicine (McGraw-Hill, 1965) the rst such book combining principles of biology, medicine, and mathematics After earning degrees in meteorology and mathematics, I worked for IBM and the space industry as a professional programmer for several years My goal at that time was to become an astronomer It was during this fork in the road that I came across Ledley s book and was fascinated by the contents and tangible hypotheses I made an appointment to see him in Washington, DC, and before the end of the visit he offered me a job (I was not looking for one) and convinced me that I should change my interest from astronomy to biomedical imaging.

I soon after went to work for him at the National Biomedical Research Foundation (NBRF), Georgetown University Medical Center, Washington, DC, from 1966 to 1980 During this period of time I also obtained my doctorate in applied mechanics and mathematics, and continued with postdoctoral studies in anatomy, physiology, and radiology Dr Ledley guided me through the design and implementation of several revolutionary medical imaging instrumentation including FIDAC ( lm input to digital automatics computer), SPIDAC (specimen input to digital automatics computer), and automatic computerized transverse axial (ACTA) whole-body CT scanner These instruments were the infants of today s lm digitizers, digital microscopes, and multislice CT scanners.

I also led or worked on research projects in chromosomes karyotyping; classi cation of pneumoconiosis on chest X-ray lms; 3-D image rendering; image subtraction; CT for radiotherapy on bone and body mass densities, diagnosis of pulmonary nodules, and cardiac imaging; and protein sequences medical database These projects were predecessors of many of today s medical imaging informatics methodologies and database concepts I further bene ted from working with Dr Ledley on soliciting for grants, designing a research laboratory, and writing a book I followed technology transfer from the university research to private industry and entrepreneurship I had the opportunity to develop innovative interdisciplinary courses combining physical and biological sciences that were taught as electives at Georgetown..

Table 2.3. Gel ltration media. A selection of commonly-used gel ltration media with their individual fractionation range and composition Resin Fractionation range kDa (globular proteins) Application

During his sentencing hearing, he was given the opportunity to address the court Rather than ask forgiveness, Lallemand stated, It s really a day for the family to seek justice 5 He never offered an apology for his crimes and was sentenced to life in prison without the possibility of parole He also agreed to testify against Lisa Toney in her trial on similar charges She was convicted and also sentenced to life in prison What started as an identity theft ended as a homicide, leaving numerous lives forever devastated..

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Figure 18-11: The electrical schematic has several symbols that would be useful as blocks 3 Choose Make Block from the Draw toolbar In the Name text box of the Block Definition dialog box, type hl switch Choose Select Objects Use a selection window to select the entire hi-limit switch box (not including the text labels) Right-click to end selection Click Pick Point in the Base Point section of the dialog box Use the Quadrant object snap to pick the left quadrant of the left circle in the switch, at 1 in Figure 18-11 Choose Retain in the Objects section Click OK The objects in this block were created on the Object layer, which is red with a continuous linetype The color, linetype, and lineweight are set to ByLayer 4 Use a selection window to select the air damper switch.

(The objects are currently on the Object layer, which is red with a continuous linetype) Click the Color Control dropdown list and choose ByBlock Do the same with the Linetype Control and the Lineweight Control drop-down lists The switch turns black (or white if you re using a black screen) The objects are still selected 5 Choose Make Block again from the Draw toolbar In the Name text box, type ad switch The dialog box says 4 objects selected Click Pick Point Use the Quadrant object snap to pick the left quadrant of the left circle in the switch Click OK 6 Use a selection window to select the top conduit symbol at 2 in Figure 18-11 (it consists of four objects) (It is currently on the Conduit layer, which is black and has a linetype of Hidden2.